human C9ORF142 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human C9orf142.
shAAV-203791
AAV-h-C9ORF142-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human C9orf142 (chromosome 9 open reading frame 142). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C9orf142; paralog of XRCC4 and XLF; protein PAXX; XLS; XRCC4-like small protein
Description (eCommerce)
C9orf142 is involved in DNA non-homologous end joining (NHEJ). It may act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double-strand break (DSB) sites [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUH6].
Gene ID
286257
Gene Name (eCommerce)
PAXX, non-homologous end joining factor
Gene Name (Vector)
chromosome 9 open reading frame 142
Gene Symbol
C9orf142
HGNC ID
HGNC:27849
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
615
ORF Size (bp)
615 bp
Protein Name (eCommerce)
Protein PAXX
RefSeq ID
NM_183241
RefSeq Synonyms
NM_183241, NM_001329678, BC002613,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
C9orf142 is involved in DNA non-homologous end joining (NHEJ). It may act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double-strand break (DSB) sites [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BUH6].
UniGene ID
Hs.409582
UniProt ID (eCommerce)
Q9BUH6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.