human C6ORF108 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human DNPH1.
shAAV-203546
AAV-h-C6ORF108-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human DNPH1 (2′-deoxynucleoside 5′-phosphate N-hydrolase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2'-deoxynucleoside 5'-phosphate N-hydrolase 1; C6orf108; c-Myc-responsive protein RCL; deoxyribonucleoside 5'-monophosphate N-glycosidase; dJ330M21.3; putative c-Myc-responsive; RCL
Description (eCommerce)
RCL catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43598].
Description (Vector)
C6orf108 was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described.
Gene ID
10591
Gene Name (eCommerce)
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Gene Name (Vector)
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Gene Symbol
DNPH1
HGNC ID
HGNC:21218
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
525
ORF Size (bp)
525 bp
Protein Name (eCommerce)
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
RefSeq ID
NM_006443
RefSeq Synonyms
NM_199184, NM_006443, BC011683,
Research Areas
Cell Biology,Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
RCL catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43598].
UniGene ID
Hs.109752
UniProt ID (eCommerce)
O43598
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.