human C4BPA shRNA silencing AAV

Name
AAV-h-C4BPA-shRNA

Cat No
shAAV-203440

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human C4BPA.

shAAV-203440

AAV-h-C4BPA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human C4BPA (complement component 4 binding protein alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C4BP; PRP

Description (Vector)

C4BPA encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster.

Gene ID

722

Gene Name (Vector)

complement component 4 binding protein alpha

Gene Symbol

C4BPA

HGNC ID

HGNC:1325

ORF Size (aa)

1794

ORF Size (bp)

1794 bp

RefSeq ID

NM_000715

RefSeq Synonyms

NM_000715, BC022312,

Species

human

UniGene ID

Hs.1012

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.