human C19ORF62 shRNA silencing AAV

Name 
AAV-h-C19ORF62-shRNA
Cat No 
shAAV-202946
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human BABAM1.

shAAV-202946
AAV-h-C19ORF62-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BABAM1 (BRISC and BRCA1 A complex member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; C19orf62; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; NBA1; new component of the BRCA1-A complex; new component of the BRCAA1 A complex
Description (eCommerce)
MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWV8].
Gene ID
29086
Gene Name (eCommerce)
BRISC and BRCA1 A complex member 1
Gene Name (Vector)
BRISC and BRCA1 A complex member 1
Gene Symbol
BABAM1
HGNC ID
HGNC:25008
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
990
ORF Size (bp)
990 bp
Protein Name (eCommerce)
BRISC and BRCA1-A complex member 1
RefSeq ID
NM_014173
RefSeq Synonyms
NM_014173, NM_001288757, NM_001288756, NM_001033549, BC091491, BC006244, BC000788,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Damage/Repair,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWV8].
UniGene ID
Hs.190722
UniProt ID (eCommerce)
Q9NWV8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.