human C16ORF57 shRNA silencing AAV

Name 
AAV-h-C16ORF57-shRNA
Cat No 
shAAV-202744
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human USB1.

shAAV-202744
AAV-h-C16ORF57-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human USB1 (U6 snRNA biogenesis phosphodiesterase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C16orf57; hUsb1; HVSL1; Mpn1; PN
Description (Vector)
USB1 encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
79650
Gene Name (Vector)
U6 snRNA biogenesis phosphodiesterase 1
Gene Symbol
USB1
HGNC ID
HGNC:25792
ORF Size (aa)
798
RefSeq ID
NM_024598
RefSeq Synonyms
NM_024598, NM_001330569, NM_001330568, NM_001204911, NM_001195302, BC021554, BC010099, BC007774, BC006291, BC004415,
Species
human
UniGene ID
Hs.588873

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.