human BSCL2 shRNA silencing AAV

Name
AAV-h-BSCL2-shRNA

Cat No
shAAV-202294

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human BSCL2.

shAAV-202294

AAV-h-BSCL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BSCL2 (BSCL2, seipin lipid droplet biogenesis associated). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GNG3LG; HMN5; PELD; SPG17

Description (Vector)

BSCL2 encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2).

Gene ID

26580

Gene Name (Vector)

BSCL2, seipin lipid droplet biogenesis associated

Gene Symbol

BSCL2

HGNC ID

HGNC:15832

ORF Size (aa)

1197

ORF Size (bp)

1197 bp

RefSeq ID

NM_032667

RefSeq Synonyms

NM_032667, NM_001130702, NM_001122955, BC093048, BC041640, BC012140, BC009866, BC004911,

Species

human

UniGene ID

Hs.715615

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.