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human BRD1 shRNA silencing AAV

Name 
AAV-h-BRD1-shRNA
Cat No 
shAAV-202254
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human BRD1.

shAAV-202254
AAV-h-BRD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BRD1 (bromodomain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BR140-like protein; BRL; bromodomain and PHD finger-containing protein 2; bromodomain-containing protein 1; BRPF1; BRPF2
Description (eCommerce)
BRD1 (bromodomain containing 1) is a bromodomain containing protein that also bears a PHD-type zinc-finger and a PWWP domain. Although little is known about its specific function, BRD1 has been found to be a component of the MOZ/MORF complex which is involved in histone acetylation. Additionally, several associations between BRD1 and schizophrenia and bipolar disorder have been made and suggest that BRD1 is a new susceptibility gene for these disorders. Immunohistochemical studies have also suggested that BRD1 may play a specific role in neuronal development.
Description (Vector)
BRD1 encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
Gene ID
23774
Gene Name (eCommerce)
bromodomain containing 1
Gene Name (Vector)
bromodomain containing 1
Gene Symbol
BRD1
HGNC ID
HGNC:1102
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3570
ORF Size (bp)
3570 bp
Protein Name (eCommerce)
Bromodomain-containing protein 1
RefSeq ID
NM_014577
RefSeq Synonyms
NM_014577, NM_001304809, NM_001304808, BC047508, BC030007,
Research Areas
Histone Modification,Neurobiology,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology,transcription_translation
Species
human
Target Sentence
BRD1 (bromodomain containing 1) is a bromodomain containing protein that also bears a PHD-type zinc-finger and a PWWP domain. Although little is known about its specific function, BRD1 has been found to be a component of the MOZ/MORF complex which is involved in histone acetylation. Additionally, several associations between BRD1 and schizophrenia and bipolar disorder have been made and suggest that BRD1 is a new susceptibility gene for these disorders. Immunohistochemical studies have also suggested that BRD1 may play a specific role in neuronal development.
UniGene ID
Hs.127950
UniProt ID (eCommerce)
O95696

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.