human BIRC3 shRNA silencing AAV

Name
AAV-h-BIRC3-shRNA

Cat No
shAAV-202147

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human BIRC3.

shAAV-202147

AAV-h-BIRC3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BIRC3 (baculoviral IAP repeat containing 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49

Description (Vector)

BIRC3 encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.

Gene ID

330

Gene Name (Vector)

baculoviral IAP repeat containing 3

Gene Symbol

BIRC3

HGNC ID

HGNC:591

ORF Size (aa)

1815

ORF Size (bp)

1815 bp

RefSeq ID

NM_001165

RefSeq Synonyms

NM_182962, NM_001165, BC037420,

Species

human

UniGene ID

Hs.127799

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.