human BCL2L2 shRNA silencing AAV

Name
AAV-h-BCL2L2-shRNA

Cat No
shAAV-202051

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human BCL2L2.

shAAV-202051

AAV-h-BCL2L2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BCL2L2 (BCL2 like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BCL-W; BCL2-L-2; BCLW; PPP1R51

Description (Vector)

BCL2L2 encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.

Gene ID

599

Gene Name (Vector)

BCL2 like 2

Gene Symbol

BCL2L2

HGNC ID

HGNC:995

ORF Size (aa)

582

ORF Size (bp)

582 bp

RefSeq ID

NM_004050

RefSeq Synonyms

NM_004050, NM_001199839, BC113522, BC104789, BC021198,

Species

human

UniGene ID

Hs.410026

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.