human BCAS1 shRNA silencing AAV

Name
AAV-h-BCAS1-shRNA

Cat No
shAAV-202015

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human BCAS1.

shAAV-202015

AAV-h-BCAS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BCAS1 (breast carcinoma amplified sequence 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AIBC1; NABC1

Description (Vector)

BCAS1 resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene.

Gene ID

8537

Gene Name (Vector)

breast carcinoma amplified sequence 1

Gene Symbol

BCAS1

HGNC ID

HGNC:974

ORF Size (aa)

1158

ORF Size (bp)

1158 bp

RefSeq ID

NM_003657

RefSeq Synonyms

NM_003657, NM_001323347, NM_001316361, BC126348, BC126346, BC024044,

Species

human

UniGene ID

Hs.400556

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.