human BBS2 shRNA silencing AAV

Name
AAV-h-BBS2-shRNA

Cat No
shAAV-201998

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human BBS2.

shAAV-201998

AAV-h-BBS2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human BBS2 (Bardet-Biedl syndrome 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BBS; RP74

Description (Vector)

BBS2 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.

Gene ID

583

Gene Name (Vector)

Bardet-Biedl syndrome 2

Gene Symbol

BBS2

HGNC ID

HGNC:967

ORF Size (aa)

2166

ORF Size (bp)

2166 bp

RefSeq ID

NM_031885

RefSeq Synonyms

NM_031885, BC014140,

Species

human

UniGene ID

Hs.333738

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.