human B4GALT6 shRNA silencing AAV

Name
AAV-h-B4GALT6-shRNA

Cat No
shAAV-201918

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human B4GALT6.

shAAV-201918

AAV-h-B4GALT6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human B4GALT6 (beta-1,4-galactosyltransferase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B4Gal-T6; beta4Gal-T6

Description (Vector)

B4GALT6 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.

Gene ID

9331

Gene Name (Vector)

beta-1,4-galactosyltransferase 6

Gene Symbol

B4GALT6

HGNC ID

HGNC:929

ORF Size (aa)

1149

ORF Size (bp)

1149 bp

RefSeq ID

NM_004775

RefSeq Synonyms

NM_004775, NM_001330570, BC074884, BC074835, BC069642, BC069620,

Species

human

UniGene ID

Hs.591063

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.