human ATP6V1C1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ATP6V1C1.
shAAV-201760
AAV-h-ATP6V1C1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP6C; ATP6D; VATC; Vma5
Description (Vector)
ATP6V1C1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. ATP6V1C1 is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.
Gene ID
528
Gene Name (Vector)
ATPase H+ transporting V1 subunit C1
Gene Symbol
ATP6V1C1
HGNC ID
HGNC:856
ORF Size (aa)
1149
ORF Size (bp)
1149 bp
RefSeq ID
NM_001695
RefSeq Synonyms
NM_001695, BC010960,
Species
human
UniGene ID
Hs.86905
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.