human ATP6V0A1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ATP6V0A1.
shAAV-201742
AAV-h-ATP6V0A1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ATP6V0A1 (ATPase H+ transporting V0 subunit a1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
a1; ATP6N1; ATP6N1A; Stv1; Vph1; VPP1
Description (Vector)
ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. ATP6V0A1 encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
535
Gene Name (Vector)
ATPase H+ transporting V0 subunit a1
Gene Symbol
ATP6V0A1
HGNC ID
HGNC:865
ORF Size (aa)
2514
ORF Size (bp)
2514 bp
RefSeq ID
NM_005177
RefSeq Synonyms
NM_005177, NM_001130021, NM_001130020, BC032398,
Species
human
UniGene ID
Hs.463074
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.