human ATP5G3 shRNA silencing AAV

Name
AAV-h-ATP5G3-shRNA

Cat No
shAAV-201724

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ATP5G3.

shAAV-201724

AAV-h-ATP5G3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATP5G3 (ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Description (Vector)

ATP5G3 encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). ATP5G3 is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified.

Gene ID

518

Gene Name (Vector)

ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9)

Gene Symbol

ATP5G3

HGNC ID

HGNC:843

ORF Size (aa)

429

ORF Size (bp)

429 bp

RefSeq ID

NM_001689

RefSeq Synonyms

NM_001689, NM_001190329, NM_001002258, BC106881,

Species

human

UniGene ID

Hs.429

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.