human ATG4D shRNA silencing AAV

Name
AAV-h-ATG4D-shRNA

Cat No
shAAV-201643

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ATG4D.

shAAV-201643

AAV-h-ATG4D-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ATG4D (autophagy related 4D cysteine peptidase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

APG4-D; APG4D; AUTL4

Description (Vector)

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.

Gene ID

84971

Gene Name (Vector)

autophagy related 4D cysteine peptidase

Gene Symbol

ATG4D

HGNC ID

HGNC:20789

ORF Size (aa)

1425

ORF Size (bp)

1425 bp

RefSeq ID

NM_032885

RefSeq Synonyms

NM_032885, NM_001281504, BC068992,

Species

human

UniGene ID

Hs.512799

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.