human ATF4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ATF4.
shAAV-201618
AAV-h-ATF4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ATF4 (activating transcription factor 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CREB-2; CREB2; TAXREB67; TXREB
Description (Vector)
ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.
Gene ID
468
Gene Name (Vector)
activating transcription factor 4
Gene Symbol
ATF4
HGNC ID
HGNC:786
ORF Size (aa)
1056
ORF Size (bp)
1056 bp
RefSeq ID
NM_001675
RefSeq Synonyms
NM_182810, NM_001675, BC073990, BC073754, BC044895, BC024775, BC022088, BC016855, BC011994, BC008090,
Species
human
UniGene ID
Hs.496487
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.