human ARPC1B shRNA silencing AAV

Name 
AAV-h-ARPC1B-shRNA
Cat No 
shAAV-201460
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ARPC1B.

shAAV-201460
AAV-h-ARPC1B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARPC1B (actin related protein 2/3 complex subunit 1B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
actin related protein 2/3 complex, subunit 1B, 41kDa; actin-related protein 2/3 complex subunit 1B; ARC41; arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; p40-ARC; p41-ARC; PLTEID
Description (eCommerce)
Arpc1b (actin-related protein 2/3 complex subunit 1B) functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Recently Arpc1b has been found to localize at centrosomes and function in centrosome homeostasis.
Description (Vector)
ARPC1B encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
Gene ID
10095
Gene Name (eCommerce)
actin related protein 2/3 complex subunit 1B
Gene Name (Vector)
actin related protein 2/3 complex subunit 1B
Gene Symbol
ARPC1B
HGNC ID
HGNC:704
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1119
ORF Size (bp)
1119 bp
Protein Name (eCommerce)
Actin-related protein 2/3 complex subunit 1B
RefSeq ID
NM_005720
RefSeq Synonyms
NM_005720, BC007555, BC002988, BC002562,
Research Areas
Cytoskeleton,Immunology,PDGF Signaling,RAC1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Arpc1b (actin-related protein 2/3 complex subunit 1B) functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Recently Arpc1b has been found to localize at centrosomes and function in centrosome homeostasis.
UniGene ID
Hs.489284
UniProt ID (eCommerce)
O15143

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.