human ARHGEF7 shRNA silencing AAV

Name
AAV-h-ARHGEF7-shRNA

Cat No
shAAV-201374

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ARHGEF7.

shAAV-201374

AAV-h-ARHGEF7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARHGEF7 (Rho guanine nucleotide exchange factor 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB

Description (Vector)

Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

8874

Gene Name (Vector)

Rho guanine nucleotide exchange factor 7

Gene Symbol

ARHGEF7

HGNC ID

HGNC:15607

ORF Size (aa)

2262

ORF Size (bp)

2262 bp

RefSeq ID

NM_003899

RefSeq Synonyms

NM_145735, NM_003899, NM_001330598, NM_001330597, NM_001320854, NM_001320853, NM_001320852, NM_001320851, NM_001113513, NM_001113512, NM_001113511, BC060776, BC033905,

Species

human

UniGene ID

Hs.508738

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.