human ARHGEF11 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ARHGEF11.
shAAV-201356
AAV-h-ARHGEF11-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ARHGEF11 (Rho guanine nucleotide exchange factor 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
glutamate transporter EAAT4-associated protein 48; GTRAP48; PDZ-RHOGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator
Description (eCommerce)
PDZ-RhoGEF. (PDZ domain-containing Rho guanine nucleotide exchange factor) catalyzes the exchange of GDP for GTP on the GTPase, Rho, to activate downstream signaling pathways. It contains a PDZ [post synaptic density protein (PSD95), Drosophila dis large tumor suppressor (DIgA), and zonula occludens-1 protein (zo-1)] domain which is an 80-90 amino acid structural domain found in signaling proteins in bacteria, yeast, plants, and animals. PDZ-RhoGEF has been shown to be important to cell migration and the regulation of adhesion movement and trailing edge retraction.
Description (Vector)
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
Gene ID
9826
Gene Name (eCommerce)
Rho guanine nucleotide exchange factor 11
Gene Name (Vector)
Rho guanine nucleotide exchange factor 11
Gene Symbol
ARHGEF11
HGNC ID
HGNC:14580
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4689
ORF Size (bp)
4689 bp
Protein Name (eCommerce)
Rho guanine nucleotide exchange factor 11
RefSeq ID
NM_014784
RefSeq Synonyms
NM_198236, NM_014784, BC057394,
Research Areas
Apoptosis,Axon Guidance,Cardiovascular,Cytoskeleton,GPCR Signaling,Neurobiology,NGF Signaling,Rho Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PDZ-RhoGEF. (PDZ domain-containing Rho guanine nucleotide exchange factor) catalyzes the exchange of GDP for GTP on the GTPase, Rho, to activate downstream signaling pathways. It contains a PDZ [post synaptic density protein (PSD95), Drosophila dis large tumor suppressor (DIgA), and zonula occludens-1 protein (zo-1)] domain which is an 80-90 amino acid structural domain found in signaling proteins in bacteria, yeast, plants, and animals. PDZ-RhoGEF has been shown to be important to cell migration and the regulation of adhesion movement and trailing edge retraction.
UniGene ID
Hs.516954
UniProt ID (eCommerce)
O15085
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.