human ARHGAP22 shRNA silencing AAV

Name
AAV-h-ARHGAP22-shRNA

Cat No
shAAV-201320

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ARHGAP22.

shAAV-201320

AAV-h-ARHGAP22-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ARHGAP22 (Rho GTPase activating protein 22). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RhoGAP2; RhoGap22

Description (Vector)

ARHGAP22 encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

58504

Gene Name (Vector)

Rho GTPase activating protein 22

Gene Symbol

ARHGAP22

HGNC ID

HGNC:30320

ORF Size (aa)

2145

ORF Size (bp)

2145 bp

RefSeq ID

NM_021226

RefSeq Synonyms

NM_021226, NM_001256026, NM_001256025, NM_001256024, BC136319, BC126444,

Species

human

UniGene ID

Hs.655672

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.