human AP4E1 shRNA silencing AAV

Name
AAV-h-AP4E1-shRNA

Cat No
shAAV-201109

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human AP4E1.

shAAV-201109

AAV-h-AP4E1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AP4E1 (adaptor related protein complex 4 epsilon 1 subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPSQ4; SPG51; STUT1

Description (Vector)

AP4E1 encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

23431

Gene Name (Vector)

adaptor related protein complex 4 epsilon 1 subunit

Gene Symbol

AP4E1

HGNC ID

HGNC:573

ORF Size (aa)

3414

ORF Size (bp)

3414 bp

RefSeq ID

NM_007347

RefSeq Synonyms

NM_007347, NM_001252127, BC130466, BC126308,

Species

human

UniGene ID

Hs.413366

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.