human ANKHD1 shRNA silencing AAV

Name 
AAV-h-ANKHD1-shRNA
Cat No 
shAAV-200932
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ANKHD1.

shAAV-200932
AAV-h-ANKHD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ANKHD1 (ankyrin repeat and KH domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ankyrin repeat and KH domain-containing protein 1; HIV-1 Vpr-binding ankyrin repeat protein; hMASK; MASK; MASK1; Multiple ankyrin repeats single KH domain; multiple ankyrin repeats, single KH-domain homolog; PP2500; VBARP
Description (eCommerce)
Ankyrin repeat and KH domain containing 1 (ANKHD1) is also known as multiple ankyrin repeats single KH domain (MASK). ANKDH1 is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival [taken from NCBI Entrez Gene (Gene ID: 54882)].
Description (Vector)
ANKHD1 encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.
Gene ID
54882
Gene Name (eCommerce)
ankyrin repeat and KH domain containing 1
Gene Name (Vector)
ankyrin repeat and KH domain containing 1
Gene Symbol
ANKHD1
HGNC ID
HGNC:24714
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7629
ORF Size (bp)
7629 bp
Protein Name (eCommerce)
Ankyrin repeat and KH domain-containing protein 1
RefSeq ID
NM_024668
RefSeq Synonyms
NM_024668, NM_017978, NM_017747, NM_001197030, BC172415, BC040231,
Research Areas
Apoptosis,RNA Binding
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Ankyrin repeat and KH domain containing 1 (ANKHD1) is also known as multiple ankyrin repeats single KH domain (MASK). ANKDH1 is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival [taken from NCBI Entrez Gene (Gene ID: 54882)].
UniGene ID
Hs.594084
UniProt ID (eCommerce)
Q8IWZ3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.