human ANAPC10 shRNA silencing AAV

Name 
AAV-h-ANAPC10-shRNA
Cat No 
shAAV-200896
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ANAPC10.

shAAV-200896
AAV-h-ANAPC10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ANAPC10 (anaphase promoting complex subunit 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
anaphase-promoting complex subunit 10; APC10; cyclosome subunit 10; DOC1
Description (eCommerce)
ANAPC10/APC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]) [taken from NCBI Entrez Gene (Gene ID: 10393)].
Description (Vector)
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 (PubMed 11524682)).(supplied by OMIM, Feb 2011)
Gene ID
10393
Gene Name (eCommerce)
anaphase promoting complex subunit 10
Gene Name (Vector)
anaphase promoting complex subunit 10
Gene Symbol
ANAPC10
HGNC ID
HGNC:24077
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
558
ORF Size (bp)
558 bp
Protein Name (eCommerce)
Anaphase-promoting complex subunit 10
RefSeq ID
NM_014885
RefSeq Synonyms
NM_014885, NM_001318367, NM_001256712, NM_001256711, NM_001256710, NM_001256709, NM_001256708, NM_001256707, NM_001256706, BC005217,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Host-Virus Interactions,Immunology,Meiosis,Signal Transduction,TGF-beta Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
ANAPC10/APC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]) [taken from NCBI Entrez Gene (Gene ID: 10393)].
UniGene ID
Hs.480876
UniProt ID (eCommerce)
Q9UM13

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.