human AMPD1 shRNA silencing AAV

Name
AAV-h-AMPD1-shRNA

Cat No
shAAV-200869

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human AMPD1.

shAAV-200869

AAV-h-AMPD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AMPD1 (adenosine monophosphate deaminase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MAD; MADA; MMDD

Description (Vector)

Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Gene ID

270

Gene Name (Vector)

adenosine monophosphate deaminase 1

Gene Symbol

AMPD1

HGNC ID

HGNC:468

ORF Size (aa)

2241

ORF Size (bp)

2241 bp

RefSeq ID

NM_000036

RefSeq Synonyms

NM_001172626, NM_000036, BC141600, BC140299,

Species

human

UniGene ID

Hs.89570

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.