human AMBRA1 shRNA silencing AAV

Name 
AAV-h-AMBRA1-shRNA
Cat No 
shAAV-200836
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human AMBRA1.

shAAV-200836
AAV-h-AMBRA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AMBRA1 (autophagy and beclin 1 regulator 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
activating molecule in beclin-1-regulated autophagy; activating molecule in BECN1-regulated autophagy protein 1; autophagy/beclin-1 regulator 1; DCAF3; DDB1 and CUL4 associated factor 3; WD repeat domain 94; WDR94
Description (eCommerce)
AMBRA1 (activating molecule in Beclin-1-regulated autophagy protein 1) is a protein that bears a WD40 domain and regulates Beclin-1-dependent autophagy. In mouse embryos AMBRA1 has been shown to be critical for neural tube development.
Gene ID
55626
Gene Name (eCommerce)
autophagy and beclin 1 regulator 1
Gene Name (Vector)
autophagy and beclin 1 regulator 1
Gene Symbol
AMBRA1
HGNC ID
HGNC:25990
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3627
ORF Size (bp)
3627 bp
Protein Name (eCommerce)
Activating molecule in BECN1-regulated autophagy protein 1
RefSeq ID
NM_017749
RefSeq Synonyms
NM_017749, NM_001300731, NM_001267783, NM_001267782, BC045609,
Research Areas
Apoptosis,Autophagy,Neurobiology,Neurodevelopment,Neurogenesis
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology
Species
human
Target Sentence
AMBRA1 (activating molecule in Beclin-1-regulated autophagy protein 1) is a protein that bears a WD40 domain and regulates Beclin-1-dependent autophagy. In mouse embryos AMBRA1 has been shown to be critical for neural tube development.
UniGene ID
Hs.654644
UniProt ID (eCommerce)
Q9C0C7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.