human ALOX5AP shRNA silencing AAV

Name
AAV-h-ALOX5AP-shRNA

Cat No
shAAV-200805

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ALOX5AP.

shAAV-200805

AAV-h-ALOX5AP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ALOX5AP (arachidonate 5-lipoxygenase activating protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FLAP

Description (Vector)

ALOX5AP encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene ID

241

Gene Name (Vector)

arachidonate 5-lipoxygenase activating protein

Gene Symbol

ALOX5AP

HGNC ID

HGNC:436

ORF Size (aa)

486

ORF Size (bp)

486 bp

RefSeq ID

NM_001629

RefSeq Synonyms

NM_001629, NM_001204406, BC018538,

Species

human

UniGene ID

Hs.507658

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.