human ADRB2 shRNA silencing AAV

Name 
AAV-h-ADRB2-shRNA
Cat No 
shAAV-200506
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ADRB2.

shAAV-200506
AAV-h-ADRB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADRB2 (adrenoceptor beta 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ADRB2R; ADRBR; B2AR; BAR; BETA2AR
Description (Vector)
ADRB2 encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. ADRB2 is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Gene ID
154
Gene Name (Vector)
adrenoceptor beta 2
Gene Symbol
ADRB2
HGNC ID
HGNC:286
ORF Size (aa)
1242
ORF Size (bp)
1242 bp
RefSeq ID
NM_000024
RefSeq Synonyms
NM_000024, BC073856, BC063486, BC012481,
Species
human
UniGene ID
Hs.591251

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.