human ADAM12 shRNA silencing AAV

Name
AAV-h-ADAM12-shRNA

Cat No
shAAV-200347

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ADAM12.

shAAV-200347

AAV-h-ADAM12-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ADAM12 (ADAM metallopeptidase domain 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN; MLTNA

Description (Vector)

ADAM12 encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM12 has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.

Gene ID

8038

Gene Name (Vector)

ADAM metallopeptidase domain 12

Gene Symbol

ADAM12

HGNC ID

HGNC:190

ORF Size (aa)

2214

ORF Size (bp)

2214 bp

RefSeq ID

NM_003474

RefSeq Synonyms

NM_021641, NM_003474, NM_001288975, NM_001288974, NM_001288973, BC060804,

Species

human

UniGene ID

Hs.594537

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.