human ACTL6B shRNA silencing AAV

Name
AAV-h-ACTL6B-shRNA

Cat No
shAAV-200295

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACTL6B.

shAAV-200295

AAV-h-ACTL6B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACTL6B (actin like 6B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACTL6; arpNalpha; BAF53B

Description (Vector)

ACTL6B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.

Gene ID

51412

Gene Name (Vector)

actin like 6B

Gene Symbol

ACTL6B

HGNC ID

HGNC:160

ORF Size (aa)

1281

ORF Size (bp)

1281 bp

RefSeq ID

NM_016188

RefSeq Synonyms

NM_016188, BC020944,

Species

human

UniGene ID

Hs.259831

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.