human ACTC1 shRNA silencing AAV

Name
AAV-h-ACTC1-shRNA

Cat No
shAAV-200278

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ACTC1.

shAAV-200278

AAV-h-ACTC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACTC1 (actin, alpha, cardiac muscle 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACTC; ASD5; CMD1R; CMH11; LVNC4

Description (Vector)

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).

Gene ID

Gene Name (Vector)

actin, alpha, cardiac muscle 1

Gene Symbol

ACTC1

HGNC ID

HGNC:143

ORF Size (aa)

1134

ORF Size (bp)

1134 bp

RefSeq ID

NM_005159

RefSeq Synonyms

NM_005159, BC009978,

Species

human

UniGene ID

Hs.118127

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.