human ACOX1 shRNA silencing AAV

Name
AAV-h-ACOX1-shRNA

Cat No
shAAV-200219

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ACOX1.

shAAV-200219

AAV-h-ACOX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ACOX1 (acyl-CoA oxidase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACOX; PALMCOX; SCOX

Description (Vector)

ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

Gene Name (Vector)

acyl-CoA oxidase 1

Gene Symbol

ACOX1

HGNC ID

HGNC:119

ORF Size (aa)

1983

ORF Size (bp)

1983 bp

RefSeq ID

NM_004035

RefSeq Synonyms

NM_007292, NM_004035, NM_001185039, BC010425, BC008767,

Species

human

UniGene ID

Hs.464137

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.