human ABLIM1 shRNA silencing AAV

Name 
AAV-h-ABLIM1-shRNA
Cat No 
shAAV-200129
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ABLIM1.

shAAV-200129
AAV-h-ABLIM1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ABLIM1 (actin binding LIM protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ABLIM; abLIM-1; Actin-binding double zinc finger protein; actin-binding double-zinc-finger protein; actin-binding LIM protein 1; actin-binding LIM protein family member 1; LIMAB1; LIMATIN
Description (eCommerce)
ABLIM1 (actin-binding LIM protein 1) was isolated as a cDNA that encoded dematin-like polypeptides in the human retina. Dematin and dematin-like proteins are actin-associated proteins that play roles in cytoskeletal regulation and morphogenesis. ABLIM1 is a LIM (Lin-11 Isl-1 mec03) motif containing protein characterized by the presences of cysteine-rich double zinc-fingers that play a role in diverse developmental programs.
Description (Vector)
ABLIM1 encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
3983
Gene Name (eCommerce)
actin binding LIM protein 1
Gene Name (Vector)
actin binding LIM protein 1
Gene Symbol
ABLIM1
HGNC ID
HGNC:78
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1206
ORF Size (bp)
1206 bp
Protein Name (eCommerce)
Actin-binding LIM protein 1
RefSeq ID
NM_002313
RefSeq Synonyms
NM_006720, NM_002313, NM_001322900, NM_001322899, NM_001322898, NM_001322897, NM_001322896, NM_001322895, NM_001322894, NM_001322893, NM_001322892, NM_001322891, NM_001322890, NM_001322889, NM_001322888, NM_001322887, NM_001322886, NM_001322885, NM_001322884, NM_001322883, NM_001322882, NM_001003408, NM_001003407, BC002448,
Research Areas
Axon Guidance,Cytoskeleton,Neurobiology
Research Areas (Faceted)
neurobiology,cell_biology
Species
human
Target Sentence
ABLIM1 (actin-binding LIM protein 1) was isolated as a cDNA that encoded dematin-like polypeptides in the human retina. Dematin and dematin-like proteins are actin-associated proteins that play roles in cytoskeletal regulation and morphogenesis. ABLIM1 is a LIM (Lin-11 Isl-1 mec03) motif containing protein characterized by the presences of cysteine-rich double zinc-fingers that play a role in diverse developmental programs.
UniGene ID
Hs.538331
UniProt ID (eCommerce)
O14639

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.