human ABCE1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ABCE1.
shAAV-200090
AAV-h-ABCE1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ABCE1 (ATP binding cassette subfamily E member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI; RNS4I
Description (Vector)
ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
Gene ID
6059
Gene Name (Vector)
ATP binding cassette subfamily E member 1
Gene Symbol
ABCE1
HGNC ID
HGNC:69
ORF Size (aa)
1800
ORF Size (bp)
1800 bp
RefSeq ID
NM_002940
RefSeq Synonyms
NM_002940, NM_001040876, BC016283,
Species
human
UniGene ID
Hs.12013
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.