human AASS shRNA silencing AAV

Name
AAV-h-AASS-shRNA

Cat No
shAAV-200037

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human AASS.

shAAV-200037

AAV-h-AASS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AASS (aminoadipate-semialdehyde synthase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LKR/SDH; LKRSDH; LORSDH

Description (Vector)

AASS encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.

Gene ID

10157

Gene Name (Vector)

aminoadipate-semialdehyde synthase

Gene Symbol

AASS

HGNC ID

HGNC:17366

ORF Size (aa)

2778

ORF Size (bp)

2778 bp

RefSeq ID

NM_005763

RefSeq Synonyms

NM_005763, BC172503, BC156456,

Species

human

UniGene ID

Hs.156738

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.