human AAAS shRNA silencing AAV

Name 
AAV-h-AAAS-shRNA
Cat No 
shAAV-200012
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human AAAS.

shAAV-200012
AAV-h-AAAS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AAAS (aladin WD repeat nucleoporin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AAA; AAASb; achalasia, adrenocortical insufficiency, alacrimia; ADRACALA; ADRACALIN; ALADIN; Allgrove, triple-A; GL003
Description (eCommerce)
Aladin is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. Aladin is part of the nuclear pore complex and is anchored there by NDC1. Defects in the coding gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome [taken from NCBI Entrez Gene (Gene ID: 8086)].
Description (Vector)
AAAS is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
8086
Gene Name (eCommerce)
aladin WD repeat nucleoporin
Gene Name (Vector)
aladin WD repeat nucleoporin
Gene Symbol
AAAS
HGNC ID
HGNC:13666
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1641
ORF Size (bp)
1641 bp
Protein Name (eCommerce)
Aladin
RefSeq ID
NM_015665
RefSeq Synonyms
NM_015665, NM_001173466, BC000659,
Research Areas
Cell Cycle,Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,metabolism
Species
human
Target Sentence
Aladin is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. Aladin is part of the nuclear pore complex and is anchored there by NDC1. Defects in the coding gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome [taken from NCBI Entrez Gene (Gene ID: 8086)].
UniGene ID
Hs.369144
UniProt ID (eCommerce)
Q9NRG9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.