human A2BP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human RBFOX1.
shAAV-200005
AAV-h-A2BP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human RBFOX1 (RNA binding protein, fox-1 homolog 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2BP1; A2BP1; FOX-1; FOX1; HRNBP1
Description (Vector)
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
54715
Gene Name (Vector)
RNA binding protein, fox-1 homolog 1
Gene Symbol
RBFOX1
HGNC ID
HGNC:18222
ORF Size (aa)
1188
ORF Size (bp)
1188 bp
RefSeq ID
NM_145891
RefSeq Synonyms
NM_145893, NM_145892, NM_145891, NM_018723, NM_001308117, NM_001142334, NM_001142333, BC113691,
Species
human
UniGene ID
Hs.459842
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.