human A2BP1 shRNA silencing AAV

Name
AAV-h-A2BP1-shRNA

Cat No
shAAV-200005

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RBFOX1.

shAAV-200005

AAV-h-A2BP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RBFOX1 (RNA binding protein, fox-1 homolog 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2BP1; A2BP1; FOX-1; FOX1; HRNBP1

Description (Vector)

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

54715

Gene Name (Vector)

RNA binding protein, fox-1 homolog 1

Gene Symbol

RBFOX1

HGNC ID

HGNC:18222

ORF Size (aa)

1188

ORF Size (bp)

1188 bp

RefSeq ID

NM_145891

RefSeq Synonyms

NM_145893, NM_145892, NM_145891, NM_018723, NM_001308117, NM_001142334, NM_001142333, BC113691,

Species

human

UniGene ID

Hs.459842

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.