rat TAP1 Adenovirus
This is an Adenovirus expressing Rat Tap1.
ADV-294551
Ad-r-TAP1
Ready-to-use Adenovirus expressing Rat Tap1 (transporter 1, ATP binding cassette subfamily B member). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Abcb2; Cim; Tap2
Description (Vector)
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Gene ID
24811
Gene Name (Vector)
transporter 1, ATP binding cassette subfamily B member
Gene Symbol
Tap1
ORF Size (aa)
2178
ORF Size (bp)
2178 bp
RefSeq ID
NM_032055
RefSeq Synonyms
NM_032055, BC101854,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.