rat SPATA18 Adenovirus
This is an Adenovirus expressing Rat Spata18.
ADV-291054
Ad-r-SPATA18
Ready-to-use Adenovirus expressing Rat Spata18 (spermatogenesis associated 18). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
spetex-1
Description (Vector)
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
Gene ID
289586
Gene Name (Vector)
spermatogenesis associated 18
Gene Symbol
Spata18
ORF Size (aa)
1707
ORF Size (bp)
1707 bp
RefSeq ID
NM_199374
RefSeq Synonyms
NM_199374, BC078996,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.