mouse PPP4R2 Adenovirus
This is an Adenovirus expressing Mouse Ppp4r2.
ADV-280997
Ad-m-PPP4R2
Ready-to-use Adenovirus expressing Mouse Ppp4r2 (protein phosphatase 4, regulatory subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BE691708; C230060M08Rik
Description (Vector)
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Gene ID
232314
Gene Name (Vector)
protein phosphatase 4, regulatory subunit 2
Gene Symbol
Ppp4r2
ORF Size (aa)
1251
ORF Size (bp)
1251 bp
RefSeq ID
NM_182939
RefSeq Synonyms
NM_182939, BC110429, BC098464, BC056340,
Species
mouse
UniGene ID
Mm.399622
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.