mouse WDR48 Adenovirus
This is an Adenovirus expressing Mouse Thegl.
ADV-276204
Ad-m-WDR48
Ready-to-use Adenovirus expressing Mouse Wdr48 (WD repeat domain 48). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
8430408H12Rik; mKIAA1449; Uaf1
Description (Vector)
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
Gene ID
67561
Gene Name (Vector)
WD repeat domain 48
Gene Symbol
Wdr48
ORF Size (aa)
1989
ORF Size (bp)
1989 bp
RefSeq ID
NM_026236
RefSeq Synonyms
NM_026236, BC062967, BC048155,
Species
mouse
UniGene ID
Mm.473239
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.