mouse USP33 Adenovirus
This is an Adenovirus expressing Mouse Ermard.
ADV-275734
Ad-m-USP33
Ready-to-use Adenovirus expressing Mouse Usp33 (ubiquitin specific peptidase 33). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9830169D19Rik; AA409780; Vdu1
Description (Vector)
Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Gene ID
170822
Gene Name (Vector)
ubiquitin specific peptidase 33
Gene Symbol
Usp33
ORF Size (aa)
2727
ORF Size (bp)
2727 bp
RefSeq ID
NM_133247
RefSeq Synonyms
NM_133247, NM_001252486, NM_001076676, BC148745, BC146302,
Species
mouse
UniGene ID
Mm.258320
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.