mouse ULK1 Adenovirus
This is an Adenovirus expressing Mouse Ulk1.
ADV-275618
Ad-m-ULK1
Ready-to-use Adenovirus expressing Mouse Ulk1 (unc-51 like kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AU041434; mKIAA0722; Unc51.1
Description (Vector)
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Gene ID
22241
Gene Name (Vector)
unc-51 like kinase 1
Gene Symbol
Ulk1
ORF Size (aa)
3174
ORF Size (bp)
3174 bp
RefSeq ID
NM_009469
RefSeq Synonyms
NM_009469, NM_001347394, BC059835, BC057121,
Species
mouse
UniGene ID
Mm.271898
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.