mouse TSC2 Adenovirus
This is an Adenovirus expressing Mouse Tsc2.
ADV-275121
Ad-m-TSC2
Ready-to-use Adenovirus expressing Mouse Tsc2 (tuberous sclerosis 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Nafld; Tcs2
Description (Vector)
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
Gene ID
22084
Gene Name (Vector)
tuberous sclerosis 2
Gene Symbol
Tsc2
ORF Size (aa)
5229
ORF Size (bp)
5229 bp
RefSeq ID
NM_011647
RefSeq Synonyms
NM_011647, NM_001286720, NM_001286718, NM_001286716, NM_001286714, NM_001286713, NM_001039363, BC060701, BC052449,
Species
mouse
UniGene ID
Mm.30435
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.