mouse ROCK1 Adenovirus
This is an Adenovirus expressing Human XDH.
ADV-270777
Ad-m-ROCK1
Ready-to-use Adenovirus expressing Mouse Rock1 (Rho-associated coiled-coil containing protein kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110055K06Rik; Rock-I
Description (Vector)
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.
Gene ID
19877
Gene Name (Vector)
Rho-associated coiled-coil containing protein kinase 1
Gene Symbol
Rock1
ORF Size (aa)
4062
ORF Size (bp)
4062 bp
RefSeq ID
NM_009071
RefSeq Synonyms
NM_009071, BC156985, BC156147,
Species
mouse
UniGene ID
Mm.6710
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.