mouse PHLPP Adenovirus

Name 
Ad-m-PHLPP
Cat No 
ADV-268562
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse Phlpp1.

ADV-268562
Ad-m-PHLPP

Ready-to-use Adenovirus expressing Mouse Phlpp1 (PH domain and leucine rich repeat protein phosphatase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AI836256; mKIAA0606; Phlpp; Plekhe1; SCOP
Description (Vector)
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.
Gene ID
98432
Gene Name (Vector)
PH domain and leucine rich repeat protein phosphatase 1
Gene Symbol
Phlpp1
ORF Size (aa)
3549
ORF Size (bp)
3549 bp
RefSeq ID
NM_133821
RefSeq Synonyms
NM_133821, BC059254,
Species
mouse
UniGene ID
Mm.24115

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.