mouse MBNL1 Adenovirus
This is an Adenovirus expressing Mouse Mbnl1.
ADV-264324
Ad-m-MBNL1
Ready-to-use Adenovirus expressing Mouse Mbnl1 (muscleblind-like 1 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Mbnl; mKIAA0428
Description (Vector)
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Gene ID
56758
Gene Name (Vector)
muscleblind-like 1 (Drosophila)
Gene Symbol
Mbnl1
ORF Size (aa)
750
RefSeq ID
NM_020007
RefSeq Synonyms
NM_020007, NM_001310514, NM_001253713, NM_001253711, NM_001253710, NM_001253709, NM_001253708, BC096600,
Species
mouse
UniGene ID
Mm.255723
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.