mouse MAML1 Adenovirus

Name 
Ad-m-MAML1
Cat No 
ADV-264140
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse Maml1.

ADV-264140
Ad-m-MAML1

Ready-to-use Adenovirus expressing Mouse Maml1 (mastermind like 1 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AI644666; AW743257; D930008C07Rik; Mam-1; Mam1; mKIAA0200
Description (Vector)
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Gene ID
103806
Gene Name (Vector)
mastermind like 1 (Drosophila)
Gene Symbol
Maml1
ORF Size (aa)
2364
ORF Size (bp)
2364 bp
RefSeq ID
NM_175334
RefSeq Synonyms
NM_175334, BC094599,
Species
mouse
UniGene ID
Mm.51116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.