mouse LRP8 Adenovirus
This is an Adenovirus expressing Mouse Lrp8.
ADV-263818
Ad-m-LRP8
Ready-to-use Adenovirus expressing Mouse Lrp8 (low density lipoprotein receptor-related protein 8, apolipoprotein e receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4932703M08Rik; AA921429; AI848122; ApoER2; Lr8b
Description (Vector)
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
Gene ID
16975
Gene Name (Vector)
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Gene Symbol
Lrp8
ORF Size (aa)
2988
ORF Size (bp)
2988 bp
RefSeq ID
NM_001080926
RefSeq Synonyms
NM_001080926, BC156400,
Species
mouse
UniGene ID
Mm.442134
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.