mouse KDM3A Adenovirus

Name
Ad-m-KDM3A

Cat No
ADV-262761

Availability
4-5 weeks

This is an Adenovirus expressing Mouse KDM3A.

ADV-262761

Ad-m-KDM3A

Ready-to-use Adenovirus expressing Mouse Kdm3a (lysine (K)-specific demethylase 3A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

1700105C21Rik; C230043E16Rik; JHDM2a; Jmjd1; Jmjd1a; KDM2A; TGSA; Tsga

Description (Vector)

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Gene ID

104263

Gene Name (Vector)

lysine (K)-specific demethylase 3A

Gene Symbol

Kdm3a

ORF Size (aa)

3972

ORF Size (bp)

3972 bp

RefSeq ID

NM_001038695

RefSeq Synonyms

NM_173001, NM_001038695, BC059264,

Species

mouse

UniGene ID

Mm.260479

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.